abstract：:Amino acids are essential for cellular metabolism, and it is important to understand how nutrient supply is coordinated with changing energy requirements during embryogenesis. Here, we show that the amino acid transporter Slc7a5/Lat1 is highly expressed in tissues undergoing morphogenesis and that Slc7a5-null mouse em...

journal_title：EMBO reports

authors： Poncet N,Halley PA,Lipina C,Gierliński M,Dady A,Singer GA,Febrer M,Shi YB,Yamaguchi TP,Taylor PM,Storey KG

更新日期：2020-01-07 00:00:00

abstract：:SUMOylation is a post-translational modification that positively regulates monoallelic expression of the trypanosome variant surface glycoprotein (VSG). The presence of a highly SUMOylated focus associated with the nuclear body, where the VSG gene is transcribed, further suggests an important role of SUMOylation in re...

journal_title：EMBO reports

authors： Saura A,Iribarren PA,Rojas-Barros D,Bart JM,López-Farfán D,Andrés-León E,Vidal-Cobo I,Boehm C,Alvarez VE,Field MC,Navarro M

更新日期：2019-12-05 00:00:00

abstract：:Spatio-temporal regulation of signalling pathways plays a key role in generating diverse responses during the development of multicellular organisms. The role of signal dynamics in transferring signalling information in vivo is incompletely understood. Here, we employ genome engineering in Drosophila melanogaster to g...

journal_title：EMBO reports

authors： Viswanathan R,Necakov A,Trylinski M,Harish RK,Krueger D,Esposito E,Schweisguth F,Neveu P,De Renzis S

更新日期：2019-12-05 00:00:00

abstract：:In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to...

journal_title：EMBO reports

authors： Sakamoto K,Furuichi Y,Yamamoto M,Takahashi M,Akimoto Y,Ishikawa T,Shimizu T,Fujimoto M,Takada-Watanabe A,Hayashi A,Mita Y,Manabe Y,Fujii NL,Ishibashi R,Maezawa Y,Betsholtz C,Yokote K,Takemoto M

更新日期：2019-11-05 00:00:00

abstract：:STK38 (also known as NDR1) is a Hippo pathway serine/threonine protein kinase with multifarious functions in normal and cancer cells. Using a context-dependent proximity-labeling assay, we identify more than 250 partners of STK38 and find that STK38 modulates its partnership depending on the cellular context by increa...

journal_title：EMBO reports

authors： Martin AP,Jacquemyn M,Lipecka J,Chhuon C,Aushev VN,Meunier B,Singh MK,Carpi N,Piel M,Codogno P,Hergovich A,Parrini MC,Zalcman G,Guerrera IC,Daelemans D,Camonis JH

更新日期：2019-11-05 00:00:00

abstract：:Research into the extreme feats of endurance that humans and some animals achieve has uncovered a range of metabolic and physiological adaptations along with their evolutionary origins. ...

journal_title：EMBO reports

authors： Hunter P

更新日期：2019-11-05 00:00:00

abstract：:Codon bias has been implicated as one of the major factors contributing to mRNA stability in several model organisms. However, the molecular mechanisms of codon bias on mRNA stability remain unclear in humans. Here, we show that human cells possess a mechanism to modulate RNA stability through a unique codon bias. Bio...

journal_title：EMBO reports

authors： Hia F,Yang SF,Shichino Y,Yoshinaga M,Murakawa Y,Vandenbon A,Fukao A,Fujiwara T,Landthaler M,Natsume T,Adachi S,Iwasaki S,Takeuchi O

更新日期：2019-11-05 00:00:00

abstract：:Hydrogen sulfide (H2 S), an endogenous signaling gaseous molecule, is involved in various physiological activities, including vessel relaxation, regulation of cellular bioenergetics, inflammation, and angiogenesis. By using xenograft orthotopic implantation of prostate cancer PC3 cells and subsequently comparing bone ...

journal_title：EMBO reports

authors： Wang YH,Huang JT,Chen WL,Wang RH,Kao MC,Pan YR,Chan SH,Tsai KW,Kung HJ,Lin KT,Wang LH

更新日期：2019-10-04 00:00:00

abstract：:The cytoplasm is the main place for protein translation from where nascent proteins are transported to their working areas, including the inside, outside, and membrane of the cell. The majority of newly synthesized membrane proteins is co-translationally inserted into the membrane by the evolutionary conserved Sec tra...

journal_title：EMBO reports

authors： Tanaka Y,Tsukazaki T

更新日期：2019-10-04 00:00:00

abstract：:Growth plasticity is a key mechanism by which plants adapt to the ever-changing environmental conditions. Since growth is a high-energy-demanding and irreversible process, it is expected to be regulated by the integration of endogenous energy status as well as environmental conditions. Here, we show that trehalose-6-p...

journal_title：EMBO reports

authors： Hwang G,Kim S,Cho JY,Paik I,Kim JI,Oh E

更新日期：2019-10-04 00:00:00

abstract：:The activation and transformation model of vertebrate nervous system formation posits that neural tissue is initially induced, or activated, with anterior forebrain character. Once established, a subset is then transformed into the more posterior midbrain, hindbrain, and spinal cord by signals emanating from the poste...

journal_title：EMBO reports

authors： Al Anber A,Martin BL

更新日期：2019-08-01 00:00:00

abstract：:Comment on "Close loop peer review" by Michael Hill. ...

journal_title：EMBO reports

authors： Horowitz A

更新日期：2019-08-01 00:00:00

abstract：:Biasing the sex ratio of populations of different organisms, including plants, insects, crustacean, and fish, has been demonstrated by genetic and non-genetic approaches. However, biasing the sex ratio of mammalian populations has not been demonstrated genetically. Here, we provide a first proof of concept for such a ...

journal_title：EMBO reports

authors： Yosef I,Edry-Botzer L,Globus R,Shlomovitz I,Munitz A,Gerlic M,Qimron U

更新日期：2019-08-01 00:00:00

abstract：:In Drosophila melanogaster males, X-chromosome monosomy is compensated by chromosome-wide transcription activation. We found that complete dosage compensation during embryogenesis takes surprisingly long and is incomplete even after 10 h of development. Although the activating dosage compensation complex (DCC) associa...

journal_title：EMBO reports

authors： Prayitno K,Schauer T,Regnard C,Becker PB

更新日期：2019-08-01 00:00:00

abstract：:Labmates are colleagues, friends, comforters…and competitors. ...

journal_title：EMBO reports

authors： Morriswood B,Hoeller O

更新日期：2019-07-01 00:00:00

abstract：:RNA binding proteins, including IMP1/IGF2BP1, are essential regulators of intestinal development and cancer. Imp1 hypomorphic mice exhibit gastrointestinal growth defects, yet the specific role for IMP1 in colon epithelial repair is unclear. Our prior work revealed that intestinal epithelial cell-specific Imp1 deletio...

journal_title：EMBO reports

authors： Chatterji P,Williams PA,Whelan KA,Samper FC,Andres SF,Simon LA,Parham LR,Mizuno R,Lundsmith ET,Lee DS,Liang S,Wijeratne HS,Marti S,Chau L,Giroux V,Wilkins BJ,Wu GD,Shah P,Tartaglia GG,Hamilton KE

更新日期：2019-06-01 00:00:00

abstract：:Oncogenic signals contribute to enhanced glycolysis and mTORC1 activity, leading to rapid cell proliferation in cancer. Regulation of glycolysis and mTORC1 by PI3K/Akt signaling is well established, but how KRAS-induced MEK signaling regulates these pathways remains poorly understood. Here, we report a role for MEK-dr...

journal_title：EMBO reports

authors： Byun JK,Park M,Yun JW,Lee J,Kim JS,Cho SJ,Lee YM,Lee IK,Choi YK,Park KG

更新日期：2019-06-01 00:00:00

abstract：:Euchromatic histone methyltransferases (EHMTs), members of the KMT1 family, methylate histone and non-histone proteins. Here, we uncover a novel role for EHMTs in regulating heterochromatin anchorage to the nuclear periphery (NP) via non-histone methylation. We show that EHMTs methylate and stabilize LaminB1 (LMNB1), ...

journal_title：EMBO reports

authors： Rao RA,Ketkar AA,Kedia N,Krishnamoorthy VK,Lakshmanan V,Kumar P,Mohanty A,Kumar SD,Raja SO,Gulyani A,Chaturvedi CP,Brand M,Palakodeti D,Rampalli S

更新日期：2019-05-01 00:00:00

abstract：:Adenosine deaminase acting on RNA (ADAR)-catalyzed adenosine-to-inosine RNA editing is potentially dysregulated in neoplastic progression. However, how this transcriptome recoding process is functionally correlated with tumorigenesis remains largely elusive. Our analyses of RNA editome datasets identify hypoxia-relate...

journal_title：EMBO reports

authors： Ma CP,Liu H,Yi-Feng Chang I,Wang WC,Chen YT,Wu SM,Chen HW,Kuo YP,Shih CT,Li CY,Tan BC

更新日期：2019-05-01 00:00:00

abstract：:Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age-dependent, cardiac-specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate heart. Mechanisticall...

journal_title：EMBO reports

authors： Ahuja G,Bartsch D,Yao W,Geissen S,Frank S,Aguirre A,Russ N,Messling JE,Dodzian J,Lagerborg KA,Vargas NE,Muck JS,Brodesser S,Baldus S,Sachinidis A,Hescheler J,Dieterich C,Trifunovic A,Papantonis A,Petrascheck M,Kli

更新日期：2019-04-01 00:00:00

abstract：:Signal peptide peptidase (SPP) and the four homologous SPP-like (SPPL) proteases constitute a family of intramembrane aspartyl proteases with selectivity for type II-oriented transmembrane segments. Here, we analyse the physiological function of the orphan protease SPPL2c, previously considered to represent a non-expr...

journal_title：EMBO reports

authors： Niemeyer J,Mentrup T,Heidasch R,Müller SA,Biswas U,Meyer R,Papadopoulou AA,Dederer V,Haug-Kröper M,Adamski V,Lüllmann-Rauch R,Bergmann M,Mayerhofer A,Saftig P,Wennemuth G,Jessberger R,Fluhrer R,Lichtenthaler SF,Lember

更新日期：2019-03-01 00:00:00

abstract：:The ubiquitin ligase Highwire restrains synaptic growth and promotes evoked neurotransmission at NMJ synapses in Drosophila Highwire regulates synaptic morphology by downregulating the MAP3K Wallenda, but excess Wallenda signaling does not account for the decreased presynaptic release observed in highwire mutants. Hen...

journal_title：EMBO reports

authors： Russo A,Goel P,Brace EJ,Buser C,Dickman D,DiAntonio A

更新日期：2019-03-01 00:00:00

abstract：:Extracellular vesicles (EVs) have been shown to carry microbial components and function in the host defense against infections. In this study, we demonstrate that Mycobacterium tuberculosis (M.tb) RNA is delivered into macrophage-derived EVs through an M.tb SecA2-dependent pathway and that EVs released from M.tb-infec...

journal_title：EMBO reports

authors： Cheng Y,Schorey JS

更新日期：2019-03-01 00:00:00

abstract：:Small non-coding miRNA appear to be vital in brain development and function by organising complex patterns of gene expression. These molecules are important for the regulation of synaptically localised mRNAs that encode proteins involved in neurotransmission and behaviour. In this issue of EMBO Reports, Lackinger et a...

journal_title：EMBO reports

authors： Cairns MJ

更新日期：2019-02-01 00:00:00

abstract：:Sirtuins (SIRTs) are a class of lysine deacylases that regulate cellular metabolism and energy homeostasis. Although sirtuins have been proposed to function in nutrient sensing and signaling, the underlying mechanism remains elusive. SIRT7, a histone H3K18-specific deacetylase, epigenetically controls mitochondria bio...

journal_title：EMBO reports

authors： Yan WW,Liang YL,Zhang QX,Wang D,Lei MZ,Qu J,He XH,Lei QY,Wang YP

更新日期：2018-12-01 00:00:00

abstract：:Microglia are specialized parenchymal-resident phagocytes of the central nervous system (CNS) that actively support, defend and modulate the neural environment. Dysfunctional microglial responses are thought to worsen CNS diseases; nevertheless, their impact during neuroinflammatory processes remains largely obscure. ...

journal_title：EMBO reports

authors： Sousa C,Golebiewska A,Poovathingal SK,Kaoma T,Pires-Afonso Y,Martina S,Coowar D,Azuaje F,Skupin A,Balling R,Biber K,Niclou SP,Michelucci A

更新日期：2018-11-01 00:00:00

abstract：:The afferent inner hair cell synapse harbors the synaptic ribbon, which ensures a constant vesicle supply. Synaptic vesicles (SVs) are arranged in morphologically discernable pools, linked via filaments to the ribbon or the presynaptic membrane. We propose that filaments play a major role in SV resupply and exocytosis...

journal_title：EMBO reports

authors： Chakrabarti R,Michanski S,Wichmann C

更新日期：2018-11-01 00:00:00

abstract：:Recent work has brought to light many different mechanisms of translation initiation that function in cells in parallel to canonical cap-dependent initiation. This has important implications for cancer. Canonical cap-dependent translation initiation is inhibited by many stresses such as hypoxia, nutrient limitation, p...

journal_title：EMBO reports

authors： Sriram A,Bohlen J,Teleman AA

更新日期：2018-10-01 00:00:00

abstract：:Endogenous retroviruses (ERVs) have accumulated in vertebrate genomes and contribute to the complexity of gene regulation. KAP1 represses ERVs during development by its recruitment to their repetitive sequences through KRAB zinc-finger proteins (KZNFs), but little is known about the regulation of ERVs in adult tissues...

journal_title：EMBO reports

authors： Tie CH,Fernandes L,Conde L,Robbez-Masson L,Sumner RP,Peacock T,Rodriguez-Plata MT,Mickute G,Gifford R,Towers GJ,Herrero J,Rowe HM

更新日期：2018-10-01 00:00:00

abstract：:The energy expending and glucose sink properties of brown adipose tissue (BAT) make it an attractive target for new obesity and diabetes treatments. Despite decades of research, only recently have mechanistic studies started to provide a more complete and consistent picture of how activated brown adipocytes handle glu...

journal_title：EMBO reports

authors： Hankir MK,Klingenspor M

更新日期：2018-09-01 00:00:00

abstract：:The Wnt signaling pathway can be grouped into two classes, the β-catenin-dependent and β-catenin-independent pathways. Wnt5a signaling through a β-catenin-independent pathway promotes microtubule (MT) remodeling during cell-substrate adhesion, cell migration, and planar cell polarity formation. Although Wnt5a signalin...

journal_title：EMBO reports

authors： Kikuchi K,Nakamura A,Arata M,Shi D,Nakagawa M,Tanaka T,Uemura T,Fujimori T,Kikuchi A,Uezu A,Sakamoto Y,Nakanishi H

更新日期：2018-07-01 00:00:00

abstract：:In Saccharomyces cerevisiae, genome stability depends on RNases H1 and H2, which remove ribonucleotides from DNA and eliminate RNA-DNA hybrids (R-loops). In Schizosaccharomyces pombe, RNase H enzymes were reported to process RNA-DNA hybrids produced at a double-strand break (DSB) generated by I-PpoI meganuclease. Howe...

journal_title：EMBO reports

authors： Zhao H,Zhu M,Limbo O,Russell P

更新日期：2018-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is the master regulator of angiogenesis, whose best-understood mechanism is sprouting. However, therapeutic VEGF delivery to ischemic muscle induces angiogenesis by the alternative process of intussusception, or vascular splitting, whose molecular regulation is essentially unk...

journal_title：EMBO reports

authors： Groppa E,Brkic S,Uccelli A,Wirth G,Korpisalo-Pirinen P,Filippova M,Dasen B,Sacchi V,Muraro MG,Trani M,Reginato S,Gianni-Barrera R,Ylä-Herttuala S,Banfi A

更新日期：2018-05-01 00:00:00

abstract：:WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11's role in development is poorly understood. Here, we report that WDR11 modulates the Hedgehog (Hh) signalling pathway ...

journal_title：EMBO reports

authors： Kim YJ,Osborn DP,Lee JY,Araki M,Araki K,Mohun T,Känsäkoski J,Brandstack N,Kim HT,Miralles F,Kim CH,Brown NA,Kim HG,Martinez-Barbera JP,Ataliotis P,Raivio T,Layman LC,Kim SH

更新日期：2018-02-01 00:00:00

abstract：:The histone H3 N-terminal protein domain (N-tail) is regulated by multiple posttranslational modifications, including methylation, acetylation, phosphorylation, and by proteolytic cleavage. However, the mechanism underlying H3 N-tail proteolytic cleavage is largely elusive. Here, we report that JMJD5, a Jumonji C (Jmj...

journal_title：EMBO reports

authors： Shen J,Xiang X,Chen L,Wang H,Wu L,Sun Y,Ma L,Gu X,Liu H,Wang L,Yu YN,Shao J,Huang C,Chin YE

更新日期：2017-12-01 00:00:00

abstract：:Understanding how cell fate decisions are regulated is a fundamental goal of developmental and stem cell biology. Most studies on the control of cell fate decisions address the contributions of changes in transcriptional programming, epigenetic modifications, and biochemical differentiation cues. However, recent studi...

journal_title：EMBO reports

authors： Tatapudy S,Aloisio F,Barber D,Nystul T

更新日期：2017-12-01 00:00:00

abstract：:Epidermal growth factor (EGF) activates the EGF receptor (EGFR) and stimulates its internalization and trafficking to lysosomes for degradation. However, a percentage of EGFR undergoes ligand-independent endocytosis and is rapidly recycled back to the plasma membrane. Importantly, alterations in EGFR recycling are a c...

journal_title：EMBO reports

authors： Ioannou MS,Kulasekaran G,Fotouhi M,Morein JJ,Han C,Tse S,Nossova N,Han T,Mannard E,McPherson PS

更新日期：2017-12-01 00:00:00

abstract：:Selenoprotein T (SelT) is a recently characterized thioredoxin-like protein whose expression is very high during development, but is confined to endocrine tissues in adulthood where its function is unknown. We report here that SelT is required for adaptation to the stressful conditions of high hormone level production...

journal_title：EMBO reports

authors： Hamieh A,Cartier D,Abid H,Calas A,Burel C,Bucharles C,Jehan C,Grumolato L,Landry M,Lerouge P,Anouar Y,Lihrmann I

更新日期：2017-11-01 00:00:00

abstract：:N6-methyladenosine (m6A) is a highly dynamic RNA modification that has recently emerged as a key regulator of gene expression. While many m6A modifications are installed by the METTL3-METTL14 complex, others appear to be introduced independently, implying that additional human m6A methyltransferases remain to be ident...

journal_title：EMBO reports

authors： Warda AS,Kretschmer J,Hackert P,Lenz C,Urlaub H,Höbartner C,Sloan KE,Bohnsack MT

更新日期：2017-11-01 00:00:00

abstract：:Cancer-associated p53 missense mutants confer gain of function (GOF) and promote tumorigenesis by regulating crucial signaling pathways. However, the role of GOF mutant p53 in regulating DNA replication, a commonly altered pathway in cancer, is less explored. Here, we show that enhanced Cdc7-dependent replication init...

journal_title：EMBO reports

authors： Datta A,Ghatak D,Das S,Banerjee T,Paul A,Butti R,Gorain M,Ghuwalewala S,Roychowdhury A,Alam SK,Das P,Chatterjee R,Dasgupta M,Panda CK,Kundu GC,Roychoudhury S

更新日期：2017-11-01 00:00:00